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Image Search Results
Journal: Cell Reports Medicine
Article Title: Predicting endometrial cancer subtypes and molecular features from histopathology images using multi-resolution deep learning models
doi: 10.1016/j.xcrm.2021.100400
Figure Lengend Snippet: Workflow and Panoptes architecture (A) A total of 456 patients in the cohorts from CPTAC and TCGA with feature annotations. (B) Overall workflow. I, H&E slide images of endometrial cancers were downloaded from databases; II, slides were separated at the per-patient level into a training, validation, and test set; III, slides were cut into 299 × 299-pixel tiles excluding background, and contaminants and qualified tiles were packaged into TFrecord files for each set; IV, training and validation sets were used to train the convolutional neural networks, and the testing set was used to evaluate trained models; V, activation maps of test set tiles were extracted and dimensionally reduced by tSNE to visualize features, while the per-tile predictions were aggregated back into intact slides; VI, an independent test set with samples from NYU hospitals was used to test the generalizability of selected best-performing models. (C) Slides were cut into paired tile sets at 2.5×, 5×, and 10× equivalent resolution of the same region to prepare for Panoptes. (D) Panoptes architecture with optional 1 × 1 convolutional layer and clinical features branch.
Article Snippet: Overall, we demonstrated that our
Techniques: Biomarker Discovery, Activation Assay